解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::ACTH/MSH(4-10) (10 micrograms/kg/b.i.d.; IP), administered to pregnant Sprague-Dawley rats during gestational days (GD) 3 to 12, significantly increased the metabolic activity of extensor digitorum longus (EDL) muscle at postnatal day 14. ACTH/MSH peptide, administered from day of birth to postnatal day 13, had no eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90128-r
更新日期:1990-01-01 00:00:00
abstract::Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90018-1
更新日期:1989-11-01 00:00:00
abstract::Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90005-3
更新日期:1989-11-01 00:00:00
abstract::We studied the effects of calcitonin gene-related peptide (CGRP) on ciliary beat frequency (CBF) and electrical properties of canine tracheal epithelium by a photoelectric method and Ussing's short-circuit technique, respectively. CGRP dose dependently increased CBF, an effect that was accompanied by elevation of intr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90183-6
更新日期:1989-09-01 00:00:00
abstract::Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90113-7
更新日期:1989-07-01 00:00:00
abstract::The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90109-5
更新日期:1989-07-01 00:00:00
abstract::The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and delta receptors, respectively. [3H]DAGO binding to mu receptors was competitively inhibited by unlabelled opioids with the following rank order of potency: DAGO gre...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90135-6
更新日期:1989-05-01 00:00:00
abstract::To determine whether a sex difference exists in the biosynthetic capacity of vasopressingergic (AVP) neurons in the bed nucleus of the stria terminalis (BNST), we have used in situ hybridization and quantitative autoradiography to measure propressophysin messenger RNA levels in these cells from adult male and female r...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90152-6
更新日期:1989-05-01 00:00:00
abstract::The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90145-9
更新日期:1989-05-01 00:00:00
abstract::Cellular uptake of [125I] labelled DSIP at the luminal interface of the blood-brain barrier (BBB) was studied in the ipsilateral perfused in situ guinea pig forebrain. Regional unidirectional transfer constants (Kin) calculated from the multiple-time brain uptake analysis were 0.93, 1.33 and 1.66 microliter.min-1 g-1 ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90026-0
更新日期:1989-03-01 00:00:00
abstract::The effects of intracerebroventricular (ICV) and intravenous injections of bombesin (BBS) on food intake were investigated in turkeys. Adult turkey hens were injected ICV with 50 to 1000 ng of BBS. In addition, the effect of pretreatment with the BBS antagonist [d-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P was investi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90030-2
更新日期:1989-03-01 00:00:00
abstract::We examined the effect of adjuvant arthritis on the content of immunoreactive calcitonin gene-related peptide (iCGRP) in the dorsal root ganglia at L4-L6 levels and the spinal cord at a lumbar level in rats. Arthritis was induced by inoculating adjuvant into both hind-paws twice at a 10 day interval. In the arthritic ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90057-0
更新日期:1989-03-01 00:00:00
abstract::There are two distinct mRNAs that encode the precursor to gastrin-releasing peptide (GRP) in rat brain. These two messages arise from separate transcription initiation sites located approximately 400 base pairs apart, which are presumably regulated by separate promoters. In the present study, we mapped the distributio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90052-1
更新日期:1989-03-01 00:00:00
abstract::Atrial dipeptidyl carboxyhydrolase readily converts one atrial natriuretic peptide, atriopeptin II (Ser103-Arg125 peptide), to another, atriopeptin I (Ser103-Ser123 peptide), by selective removal of the C-terminal dipeptide, Phe-Arg. The atrial peptides possess natriuretic, diuretic, smooth muscle relaxant, and cardio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90077-6
更新日期:1989-01-01 00:00:00
abstract::The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90074-0
更新日期:1989-01-01 00:00:00
abstract::Male Holtzman albino and Long-Evans hooded rats were administered one microgram of arginine vasopressin (AVP) or a placebo each day after the acquisition trials of a visual white-black discrimination. Animals were then trained in the reversal of the discrimination. Performance was assessed by the number of trials to c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90099-5
更新日期:1989-01-01 00:00:00
abstract::Previous reports have demonstrated that systemic injection of cholecystokinin (CCK) in rats produces dose-related decreases in food intake, increases in neurohypophyseal secretion of oxytocin (OT), and decreases in gastric emptying. The present studies determined whether systemic injection of bombesin (BBS), another p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90194-5
更新日期:1988-11-01 00:00:00
abstract::The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg.kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute alt...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(88)90098-8
更新日期:1988-09-01 00:00:00
abstract::The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90117-9
更新日期:1988-07-01 00:00:00
abstract::In these studies the pattern of feeding behavior during continuous intraventricular (IVT) infusion of NPY for 4 hr in the satiated female rat was monitored. Whereas saline infusion was ineffective, each of the three doses of NPY (117, 470 or 1175 pmol/hr) increased feeding during the entire 4 hr infusion and 2 hr post...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90112-x
更新日期:1988-07-01 00:00:00
abstract::An antiserum directed against the COOH-terminal region of neuropeptide K-(1-24)-peptide that shows only 0.5% reactivity with neuropeptide K has been used in radioimmunoassay to study the posttranslation processing of human beta-preprotachykinin. A primary midgut carcinoid tumor contained high concentration of substanc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90134-9
更新日期:1988-07-01 00:00:00
abstract::The effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the brain receptors for thyrotropin releasing hormone (TRH) was investigated. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). 3H-MeTRH bound specifically to rat brain membranes at...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90120-9
更新日期:1988-07-01 00:00:00
abstract::Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90131-3
更新日期:1988-07-01 00:00:00
abstract::The purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (CCK) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. Guide cannula for repeated push-pull perfusion were implanted bilaterally in th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90175-1
更新日期:1988-05-01 00:00:00
abstract::Two molecular forms of gonadotropin-releasing hormone (GnRH) were identified in the extracts of various brain areas, spinal cord and pituitary in female and male goldfish and had chromatographic and immunological properties similar to [His5, Trp7, Tyr8]-GnRH (cGnRH-II) and [Trp7,Leu8]-GnRH (sGnRH). Radioimmunoassay us...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90174-x
更新日期:1988-05-01 00:00:00
abstract::A study was made of the effect of adrenalectomy over different periods of time (6, 15 and 21 days) on exocrine pancreatic secretion in the rat in basal conditions and under stimulation with CCK. It was observed that adrenalectomy does not alter the rate of pancreatic flow but the response capacity to CCK is depressed....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90153-2
更新日期:1988-05-01 00:00:00
abstract::A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90149-0
更新日期:1988-05-01 00:00:00
abstract::In the conscious dog migrating and nonmigrating colonic motor complexes (CMC) were recorded by means of chronically implanted strain gauge force transducers. Intravenous injection of a synthetic enkephalin analogue immediately induced a premature CMC at all three recording sites of the colon. Naloxone inhibited the en...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90155-6
更新日期:1988-05-01 00:00:00
abstract::Cholecystokinin octapeptides (CCK8s) have been purified from methanol extracts of two brains from each of two Australian marsupials, Tammar Wallaby and Eastern Quoll, containing 3 nmol and 2 nmol of the peptides, respectively. Immunoreactive CCK was concentrated on QMA SepPak cartridges and purified by two successive ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90280-x
更新日期:1988-03-01 00:00:00
abstract::This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(88)90239-2
更新日期:1988-01-01 00:00:00
abstract::Intracerebroventricular injections of rat hypothalamic growth hormone-releasing factor (rhGRF) were examined for effects on food intake in free-feeding rats. It was found that, in picomole doses, rhGRF had a stimulatory effect on food intake. Examination of higher doses of rhGRF revealed a decrease in the facilitatory...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90220-3
更新日期:1988-01-01 00:00:00
abstract::In the Nucleus Ambiguus (NA) mu-receptors increased mean arterial pressure (MAP) and heart rate (HR) and kappa-receptors decreased MAP without altering HR. Mu-receptors in the Dorsal Motor Nucleus of the Vagus (DMV) increased MAP without changing HR whereas kappa-receptors in the DMV decreased HR without changing MAP....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90225-2
更新日期:1988-01-01 00:00:00
abstract::Using the indirect immunofluorescence method, enkephalin-like immunoreactivity was visualized on human fetus spinal cord sections (gestational age from 17 to 25 weeks). Immunolabeled varicose fibers and terminal-like structures were seen through the whole length fetal spinal cord principally in the dorsal gray, in the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90018-6
更新日期:1988-01-01 00:00:00
abstract::Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90249-5
更新日期:1988-01-01 00:00:00
abstract::The present study demonstrates the occurrence of substance P (SP)- and calcitonin gene related peptide (CGRP)-immunoreactive nerve fibres in bone, bone marrow, periosteum, synovial membrane and soft tissues adjacent to the bone. The distribution pattern of the two types of nerves was similar, although the CGRP-positiv...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90023-x
更新日期:1988-01-01 00:00:00
abstract::The leucosulfakinins (LSKs), isolated from head extracts of the cockroach Leucophaea maderae, are sulfated neuropeptides with homology to gastrin and cholecystokinin. The undecapeptide LSK and decapeptide LSK-II stimulate contractions of the isolated cockroach hindgut. Several structural aspects of the two gastrin/CCK...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90237-9
更新日期:1988-01-01 00:00:00
abstract::VIP receptors on blood mononuclear leucocytes and plasma VIP concentrations were studied during a ranger training course lasting for five days with almost continuous physical activity, and energy deficiency. The maximum binding capacity (Bmax) for the high affinity receptor increased (p less than 0.0005) from 0.71 (SE...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90025-3
更新日期:1988-01-01 00:00:00
abstract::Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90140-9
更新日期:1987-11-01 00:00:00
abstract::Unilateral intracerebroventricular (ICV) injections of a high dose of CCK7 have been reported to elicit barrel rotations accompanied by contralateral postural asymmetry; there was no spontaneous locomotor activity other than barrel rolling. The aim of the present study was to investigate the effects of lower doses of ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90126-4
更新日期:1987-11-01 00:00:00
abstract::Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90127-6
更新日期:1987-11-01 00:00:00